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Safflower Seed Oil is a seed oil produced by pressing the seeds of the safflower plant. Its main use is as a cooking oil. It also has some uses in skin care. Safflower Seed Oil is lower in saturated fatty acids than corn oil, olive oil, and most other cooking oils.1 Foods that are high in these types of fats can lead to higher cholesterol levels, which can increase your risk of heart disease. While Safflower Seed Oil may help improve your health, it may also increase pro-inflammatory substances in the body due to its content of omega-6 fatty acids. This could raise the risks of certain chronic diseases.